On Saturday June 22, 1861, at about 16:00, a fire was spotted in Cotton's Wharf, on Tooley Street. It is believed to have been started when a worker in the wharf dropped a cigarette, but this is not confirmed.
Despite Cotton's Wharf having sturdy fire protection, the surrounding buildings were less protected and the fire spread quickly, especially with the goods held in Cotton's Wharf. These included rice, tallow, hemp, jute and sugar.
At around 17:00 the London Fire Engine Establishment were informed and joined the two private fire engines, from a local distiller, that were already on the scene.
By 18:00 there were 14 fire engines trying to extinguish the blaze. The River Thames was at low tide, so the river fire engine could not be used as it was unable to draw water from the shallow water.
Soon, though, the blaze became so great that the fire engines were forced to retreat as spice warehouses caught light, distributing spices into the air.